Cell Stem Cell Resource DynamicAnalysisofGeneExpressionandGenome-wide Transcription Factor Binding during Lineage Specification of Multipotent Progenitors

Gillian May,1,2,10 Shamit Soneji,1,2,7,10 Alex J. Tipping,1,2,8 Jose Teles,1,3 Simon J. McGowan,4 Mengchu Wu,5 Yanping Guo,1,2 Cristina Fugazza,1,2 John Brown,1,2 Göran Karlsson,1,7 Cristina Pina,1,2,9 Victor Olariu,3 Stephen Taylor,4 Daniel G. Tenen,5,6 Carsten Peterson,3 and Tariq Enver1,2,* 1Stem Cell Group, UCL Cancer Institute, University College London, London WC1E 6BT, UK 2Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK 3Computational Biology and Biological Physics, Department of Theoretical Physics, Lund University, 223 62 Lund, Sweden 4Computational Biology Research Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK 5Cancer Science Institute, National University of Singapore, Singapore 117599 6Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA 7Present address: Lund Stem Cell Center, Lund University Hospital, Biomedical Centre, 221 84 Lund, Sweden 8Present address: National Health Service Blood and Transplant, John Radcliffe Hospital, Nuffield Division of Clinical Laboratory Sciences, University of Oxford, Oxford OX3 9DU, UK 9Present address: National Health Service Blood and Transplant, Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK 10These authors contributed equally to this work *Correspondence: [email protected] http://dx.doi.org/10.1016/j.stem.2013.09.003